Morgan odontogenic tumors comprise a range of disorders of growth, from malignant and benign. Maxillary clear cell odontogenic carcinoma a rare entity. Ghost cell odontogenic carcinoma gcoc is the malignant counterpart of calcifying cystic odontogenic tumour and dentinogenic ghost cell tumour. Odontogenic ghost cell carcinoma ogcc, a malignant counterpart of the calcifying odontogenic cyst coc, is exceedingly rare. Sclerosing odontogenic carcinoma soc was first fully described in 2008. Ameloblastic carcinoma, calcifying odontogenic cyst, ghost cell carcinoma, keratinizing epithelial odontogenic cyst, maxillary tumor, odontogenic carcinoma. An aggressive intraosseous lesion derived from embryonic connective tissue associated with. Odontogenic tumor article about odontogenic tumor by the. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant. Ghost cell odontogenic carcinoma gcoc is a rare malignant. Squamous cell carcinoma scc in a survey of dogs with oropharyngeal tumors, scc was the second most frequently diagnosed oral tumor 24. Odontogenic tumors comprise a complex group of lesions with varied histopathological and clinical features. Pdf ghost cell odontogenic carcinoma gcoc is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. Although potentially locally destructive, okc is a benign odontogenic process that.
Background clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults. Some tumors are true neoplasms, while some are hamartomas developmental. Study 52 odontogenic tumors flashcards from dental s. Calcifying cystic odontogenic tumor ccot is defined as an odontogenic cyst like benign neoplasm that characteristically contains several. This book greatly expands the body of knowledge in the field of odontogenic tumor pathology. Pdf ghost cell odontogenic carcinoma of the maxilla. Clear cell odontogenic carcinoma it is a lowgrade carcinoma that is composed of cells that show uniform nuclei and clear cytoplasm. Ghost cell odontogenic carcinoma gcoc is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics.
An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes. Nevoid basal cell carcinoma syndrome gorlin goltz syndrome ccot calcifying cystic odontogenic tumor derived from odontogenic epithelial cell rest. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Ghost cell odontogenic carcinoma is an extremely rare odontogenic tumor with unclear etiology.
Calcifying ghost cell odontogenic tumor cgcot was first described by gorlin et al. Ccot, dgct and gcoc cases retrieved from the files of the oral pathology. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Basal cell carcinoma basal cell carcinoma doesnt invade oral cavity unless it comes there by infiltration from skin surface.
Multiple basal cell carcinomas multiple jaw cysts odontogenic keratocysts numerous bone abnormalities including bi. Odontogenic tumors at university of colorado health. Clear cell odontogenic tumora new histologic variant with aggressive potential. Ghost cell odontogenic carcinoma, aggressive epithelial ghost cell odontogenic tumor, dentinogenic ghost cell ameloblastoma, carcinoma arising in a coc, and malignant calcifying ghost cell.
Calcifying ghost cell odontogenic cyst is comparatively rare in occurrence, constituting about 0. Pathogenesis and nomenclature of odontogenic carcinomas. Previous descriptions of this tumor were based on identification of. This definition appears very rarely and is found in the following acronym finder categories. It describes the epidemiologic, radiologic, and histopathologic features of presently known neoplasms. Odontogenic carcinoma arising from benign odontogenic. The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. Its course is unpredictable, ranging from lo cally invasive tumors of slow growth to highly aggressive and infiltrative ones. Request permission export citation add to favorites track citation. Although known by many names, the basic histologic identifying feature includes the identification of. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic tumor, only 37 cases of gcoc have been reported in the englishlanguage literature to date. Odontogenic ghost cell carcinoma johns hopkins university.
Odontogenic tumors encompass a group of lesions that share a common origin from odontogenic tissues. Squamous cell carcinoma scc arising within the lining of an odontogenic keratocyst okc is a rare occurrence. Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. Squamous cell carcinoma arising within a maxillary. Clear cell odontogenic carcinoma ghost cell odontogenic. Lim, md1, odontogenic ghost cell carcinoma of the maxilla jose m. Odontogenic cysts can give rise to a variety of neoplasms. This is the case of a middleaged male who presented.
Ameloblastic carcinoma, calcifying odontogenic cyst, ghost cell carcinoma, keratinizing epithelial odontogenic cyst, maxillary tumor. Until now, only 31 cases of ogccs have been reported in literature. It usually occurs in elderly persons with a slight male predilection. Pdf calcifying odontogenic cyst, dentinogenic ghost cell tumor. Although known by many names, the basic histologic identifying feature includes the identification of the ghost cells and the malignant changes associated with the cells. Odontogenic ghost cell carcinoma with pulmonary metastasis. Avila, md2 1department of pathology philippine general hospital university of the philippines manila.
They may arise from the epithelial part of the tooth germ, the mesenchymal part or from both. Cellular atypia, mitotic activity, ki67 labeling index and matrix metalloprotease9 positive expression rate were all increased in the currently resected specimen compared to the initial one. Dentinogenic ghost cell tumor is a rare tumor constituting only 11. Calcifying ghost cell odontogenic tumor cgcot with. This case presents an additional case, a 47yearold chinese man presented with a slowgrowing mandibular lesion with history of ameloblastoma. Ghost cell odontogenic carcinoma arising from calcifying. It most often affects the posterior mandible and most commonly presents in the third decade of life. Consequently, the name clear cell odontogenic carcinoma was thought to be more appropriate in view of the malignant potential manifested by this neoplastic lesion 2022. Calcifying odontogenic cyst was described first by gorlin et al.
Other tumours, such as calcifying epithelial odontogenic tumour pindborg tumour and ghost cell lesions. The chart showing pdf series, word series, html series, scan qr codes. This lesion is a member of the family of ghost cell lesions. Odontogenic ghost cell carcinoma ogcc is a rare odontogenic tumor characterized by the presence of ghost cells. Pdf ghost cell odontogenic carcinoma arising from calcifying. Odontogenic ghost cell carcinoma ogcc is a rare neoplastic variant of calcifying odontogenic cyst, with aggressive clinical characteristics. Dgct is a locally invasive odontogenic neoplasm characterised by. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional. A ghost cell is an enlarged eosinophilic epithelial cell with eosinophilic cytoplasm but without a nucleus. Clear cell odontogenic carcinoma mimicking a cystic lesion.
Case report mandibular ghost cell odontogenic carcinoma. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5 th 7 th decades and shows a female preponderance. The sqamous cell carcinoma should also be considered because of cytological pleomorphism and intercellular bridges2. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic tumor, only 37 cases of gcoc have been reported in the. Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. Ghost cell odontogenic carcinoma with suspected cholesterol. Primary intraosseous squamous cell carcinoma arising in.
Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic tumor with aggr. We describe a case of gcoc which was considerably derived from a previously resected calcifying cystic odontogenic tumor ccot. International collaborative study on ghost cell odontogenic tumours. An external file that holds a picture, illustration, etc.
The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al. The cystic lesions are termed as calcifying cystic odontogenic tumors ccot and the neoplastic entity as a dentinogenic ghost cell tumordgct. Ghost cell odontogenic carcinoma on right mandible and its. Calcifying epithelial odontogenic tumor of the maxilla. Calcifying cystic odontogenic tumor ccot is defined as an odontogenic cystlike benign neoplasm that characteristically contains several. The clear cell variant of ceot can be mistaken for clear cell odontogenic. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma. Ghost cell carcinoma is a rare odontogenic carcinoma. Carcinoma arising in a dentigerous cyst is extremely rare, with. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor with predominance in the posterior mandible, usually occurring in the fifth to seventh decades of life, and being found more commonly in.
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